Researchers have long suspected that the buildup of plaques made of clumps of a protein called amyloid-beta leads to cognitive decline and Alzheimer’s disease.

Now, a new study suggests it may not be the amount of plaque buildup, but the location in the brain where the clumps of abnormal proteins in the brain are being developed.

Researchers believe tracing the sites of plaque buildup can be used to predict the overall risk of Alzheimer’s disease.

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