Protein receptor signals Alzheimer’s breakthrough

A new discovery at the Yale School of Medicine has uncovered a key component to understanding and curing Alzheimer’s disease.

The neurofibrillary tangling and degradation of links between neurons characteristic of Alzheimer’s is the result of a long chain of protein interactions that has intrigued researchers for decades. Scientists at the Medical School have recognized a receptor called metabotropic glutamate receptor 5, or mGluR5, as the missing link in the chain of biological processes leading to Alzheimer’s disease. The findings on mGluR5 were published in the journal Neuron on Sept. 4.

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